# Relapsing Polychondritis Associated With Thyroid Carcinoma: A First Malagasy Case

**Authors:** Oliva Henintsoa Rakotonirainy, Mamonjisoa Olivier Andrianiaina, Lalao Nomenjanahary Rakotonirina, Volatantely Ratovonjanahary, Fahafahantsoa Rabenja Rapelanoro

PMC · DOI: 10.1155/crot/1456640 · Case Reports in Otolaryngology · 2025-04-11

## TL;DR

This paper reports the first case in Madagascar of a rare disease called relapsing polychondritis linked to thyroid cancer in a 48-year-old man.

## Contribution

The novelty is the first documented case of RP associated with thyroid carcinoma in Madagascar.

## Key findings

- A 48-year-old man presented with RP type one and papillary thyroid carcinoma.
- The RP symptoms included auricular, tracheobronchial chondritis, and episcleritis.
- This case highlights the rare paraneoplastic association between RP and thyroid cancer.

## Abstract

Relapsing polychondritis (RP) is a rare disease characterized by recurrent systemic inflammation affecting cartilaginous tissues and proteoglycan-rich tissues. The disease may present in several clinical variants, which can delay diagnosis. Corticosteroids are the treatment of choice for RP. In rare cases, RP can be paraneoplastic. The association of RP with thyroid cancer is unusual. We report the first Malagasy case of a 48-year-old man with RP type one diagnosed within less than a year, presenting with recurrent chondritis of the auricular cartilage, tracheobronchial chondritis, and recurrent episcleritis. The disease was associated with papillary thyroid carcinoma.

## Linked entities

- **Diseases:** relapsing polychondritis (MONDO:0019125), thyroid cancer (MONDO:0002108), papillary thyroid carcinoma (MONDO:0005075)

## Full-text entities

- **Diseases:** chondritis (MESH:D013991), chondritis of the auricular cartilage (MESH:D004428), systemic inflammation (MESH:D007249), papillary thyroid carcinoma (MESH:D000077273), episcleritis (MESH:D015423), Thyroid Carcinoma (MESH:D013964), RP (MESH:D011081)

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12008485/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12008485/full.md

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Source: https://tomesphere.com/paper/PMC12008485