# Age‐Related Long‐Term Longitudinal Changes in Left Ventricular Mechanical Function in Breast Cancer Patients Undergoing Anthracycline and Trastuzumab Treatment

## TL;DR

Older breast cancer patients are more vulnerable to heart damage from certain cancer treatments, highlighting the need for careful heart monitoring.

## Contribution

The study emphasizes the role of age in chemotherapy-induced heart risks and advocates for tailored cardiac monitoring in HER2-positive breast cancer patients.

## Key findings

- Age significantly affects the severity of cardiotoxicity in HER2-positive breast cancer patients.
- Comprehensive cardiac monitoring is essential before, during, and after treatment with anthracycline and trastuzumab.
- Tailored assessments can help mitigate heart complications while maintaining treatment efficacy.

## Abstract

Age significantly influences the severity of chemotherapy‐induced cardiotoxicity (cardiotoxicity) in HER2‐positive breast cancer patients. Comprehensive cardiac monitoring before, during, and after anthracycline and trastuzumab regimens is essential. Tailored assessments can help identify vulnerable patients, optimize treatment, and mitigate risks of heart complications while maintaining therapy efficacy.