# RETRACTION: Adiponectin Protects Skeletal Muscle From Ischaemia–Reperfusion Injury in Mice through miR‐21/PI3K/Akt Signalling Pathway

PMC · DOI: 10.1111/iwj.70562 · International Wound Journal · 2025-04-18

## TL;DR

This retracted paper claimed that adiponectin protects skeletal muscle from injury in mice via a specific signaling pathway.

## Contribution

The paper proposed a novel mechanism involving miR-21/PI3K/Akt signaling in the protective role of adiponectin.

## Key findings

- Adiponectin was reported to reduce skeletal muscle injury in mice.
- The miR-21/PI3K/Akt pathway was suggested as a key mediator of this protection.

## Abstract

RETRACTION:

ZhouM.
, 
ZhangH.
, 
ChenH.
, and 
QiB.
, “Adiponectin Protects Skeletal Muscle From Ischaemia–Reperfusion Injury in Mice through miR‐21/PI3K/Akt Signalling Pathway,” International Wound Journal
20, no. 5 (2023): 1647–1661, 10.1111/iwj.14022.36426910
PMC10088838

The above article, published online on 25 November 2022, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons Ltd. Following an investigation by the publisher, all parties have concluded that this article was accepted solely on the basis of a compromised peer review process. The editors have therefore decided to retract the article. The authors did not respond to our notice regarding the retraction.

## Linked entities

- **Genes:** MIR21 (microRNA 21) [NCBI Gene 406991], PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) [NCBI Gene 5290], AKT1 (AKT serine/threonine kinase 1) [NCBI Gene 207]
- **Species:** Mus musculus (taxon 10090)

## Full-text entities

- **Genes:** Mir21a (microRNA 21a) [NCBI Gene 387140] {aka Mir21, Mirn21, mmu-mir-21, mmu-mir-21a}, Adipoq (adiponectin, C1Q and collagen domain containing) [NCBI Gene 11450] {aka 30kDa, APN, Acdc, Acrp30, Ad, Adid}, Akt1 (Akt serine/threonine kinase 1) [NCBI Gene 11651] {aka Akt, LTR-akt, PKB, PKB/Akt, PKBalpha, Rac}
- **Diseases:** Ischaemia (MESH:D007511)
- **Species:** Mus musculus (house mouse, species) [taxon 10090]

## Full text

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Source: https://tomesphere.com/paper/PMC12008032