# Multidisciplinary Care of Incidental Small Renal Masses After Cancer Remission

**Authors:** Vivie Tran, Megan T Mai, Sai Kodam, Luis Brandi, Simeon Jaggernauth

PMC · DOI: 10.7759/cureus.80857 · Cureus · 2025-03-19

## TL;DR

A 72-year-old cancer survivor with a new kidney mass required careful evaluation to determine if it was a new cancer or a lymphoma recurrence.

## Contribution

The paper emphasizes the importance of biopsy and multidisciplinary care in managing small renal masses in cancer survivors.

## Key findings

- A biopsy confirmed the renal mass was clear cell RCC, not a recurrence of DLBCL.
- The patient underwent nephrectomy with no metastasis or lymphoma recurrence observed.
- Radiation therapy is suggested as an alternative when surgery is too risky.

## Abstract

This case report presents a 72-year-old male with a history of diffuse large B-cell lymphoma (DLBCL) who was found to have a 2.6 cm left renal mass during surveillance imaging. The clinical challenge lay in distinguishing between a recurrence of DLBCL and a new primary renal cell carcinoma (RCC), as both diseases are treated with different paradigms. A biopsy confirmed clear cell RCC, and the patient underwent a left nephrectomy with no evidence of metastasis or recurrence of lymphoma. This case highlights the importance of a biopsy in clarifying the diagnosis of renal masses, particularly in patients with prior malignancies. It also explores the potential role of radiation therapy as an alternative treatment option in cases where surgery may pose significant risks. A more comprehensive multidisciplinary approach would optimize patient outcomes and ensure individualized care.

## Linked entities

- **Diseases:** diffuse large B-cell lymphoma (MONDO:0018905), clear cell renal cell carcinoma (MONDO:0005005)

## Full-text entities

- **Diseases:** RCC (MESH:D002292), Renal Masses (MESH:C536030), lymphoma (MESH:D008223), DLBCL (MESH:D016403), Cancer (MESH:D009369)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12007989/full.md

## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12007989/full.md

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Source: https://tomesphere.com/paper/PMC12007989