# A Case Report of a 61-Year-Old Woman With Jaundice and Cholelithiasis Presenting With Autoimmune Hepatitis

**Authors:** Nicholas P Michalakis, Archit Patel, Muhammad Awais

PMC · DOI: 10.7759/cureus.80829 · Cureus · 2025-03-19

## TL;DR

This case report describes a 61-year-old woman with jaundice and gallstones who was diagnosed with autoimmune hepatitis, highlighting the disease's varied presentation.

## Contribution

The novelty lies in presenting a rare case of AIH with atypical symptoms to aid in early detection and treatment.

## Key findings

- The patient exhibited mixed intra- and extrahepatic findings based on initial lab results.
- The case highlights the importance of considering AIH in patients with atypical symptoms like jaundice and rash.
- Early detection and treatment of AIH can be improved by recognizing such complex presentations.

## Abstract

Autoimmune hepatitis (AIH) is a complex disease with a chronic cell-mediated immunologic process against healthy liver cells. The clinical presentation can vary since the exact cause of AIH is multifactorial. Here, we report a case of a 61-year-old woman with a past medical history of post-traumatic stress disorder and hypothyroidism who presented clinically with diffuse abdominal distention, nausea, vomiting, jaundice, rash on the torso and legs, and tea-burnt orange urine. The patient underwent an initial workup with a complete blood count (CBC), comprehensive metabolic panel (CMP), and gamma-glutamyl transpeptidase (GGT), with results leading towards a mixed intra- and extrahepatic process. This report will show various findings related to AIH to improve the detection and treatment of these patients early on.

## Linked entities

- **Diseases:** Autoimmune hepatitis (MONDO:0016264), post-traumatic stress disorder (MONDO:0005146), hypothyroidism (MONDO:0005420), cholelithiasis (MONDO:0012672)

## Full-text entities

- **Genes:** LOC102724197 (inactive glutathione hydrolase 2) [NCBI Gene 102724197] {aka GGT2}
- **Diseases:** abdominal distention (MESH:D000007), Cholelithiasis (MESH:D002769), AIH (MESH:D019693), rash (MESH:D005076), post-traumatic stress disorder (MESH:D013313), nausea (MESH:D009325), Jaundice (MESH:D007565), vomiting (MESH:D014839), hypothyroidism (MESH:D007037)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

5 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12007933/full.md

## References

29 references — full list in the complete paper: https://tomesphere.com/paper/PMC12007933/full.md

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Source: https://tomesphere.com/paper/PMC12007933