# An Alarming Sign: Acute Limb Ischemia in Patients With COVID-19

## TL;DR

Acute limb ischemia can occur weeks or months after recovering from COVID-19, requiring early diagnosis to prevent limb damage.

## Contribution

Highlights late-onset acute limb ischemia as a rare but serious complication of post-COVID-19 recovery.

## Key findings

- ALI may present weeks to months after recovery from COVID-19, complicating diagnosis.
- Persistent prothrombotic state after infection contributes to thrombus formation.
- Early diagnosis and treatment are essential to prevent irreversible limb damage.

## Abstract

Acute limb ischemia (ALI) can occur as a late complication in patients recovering from COVID-19. Although typically seen during the acute phase, ALI may present weeks to months later, making diagnosis more challenging. Symptoms, including acute limb pain, pallor, coldness, and absent pulses, can be misattributed to other post-viral issues. COVID-19 induces a prothrombotic state that persists after recovery, with increased D-dimer, fibrinogen, and endothelial dysfunction contributing to thrombus formation. Early diagnosis through clinical assessment and imaging is crucial to prevent irreversible limb damage. Treatment involves anticoagulation, revascularization, and supportive care, tailored to the patient's condition. Vigilance for late-onset ALI in post-COVID-19 patients is essential to improve outcomes and prevent limb loss.