Long‐Lasting Cross‐Linked PLGA‐Inspired Nanoparticles from One‐Pot Nanopolymerization of Precisely Sequenced Short Oligolactoglycolic Acid Dimethacrylates
Luka Blagojevic, Nazila Kamaly
TL;DR
A new method creates stable, long-lasting nanoparticles for drug delivery by precisely sequencing short monomers and encapsulating drugs during formation.
Contribution
A novel one-pot nanopolymerization technique for creating cross-linked, sequence-controlled PLGA-inspired nanoparticles with enhanced stability and drug encapsulation.
Findings
NPs made with sequence-controlled monomers show minimal pH change and heightened stability over five weeks.
The method allows for simultaneous nanoparticle formation and efficient encapsulation of drugs like dexamethasone.
The nanoparticles exhibit low cytotoxicity and uniform cellular uptake in vitro.
Abstract
A novel PLGA‐inspired NP polymerization technique is presented, which allows the formation of NPs via the cross‐linking of precisely sequenced short oligolactoglycolic acid dimethacrylates (OLGADMAs). Following the synthesis of a range of OLGADMAs, a library of NPs via this rapid and surfactant‐free nanopolymerization method is successfully generated, which permits the simultaneous NP formation and encapsulation of drugs such as dexamethasone. The results indicate that NPs produced through this nanopolymerization technique with precisely controlled sequences exhibit heightened stability compared to conventionally sequenced and non‐sequence controlled PLGA, as evidenced by minimal pH changes over five weeks. This improved stability is attributed to simultaneous crosslinking and co‐polymerization of the OLGADMAs. Moreover, the long‐acting NPs demonstrate minimal cytotoxicity and uniform…
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Taxonomy
TopicsGraphene and Nanomaterials Applications · Advanced Drug Delivery Systems · Nanoparticle-Based Drug Delivery