# Temporal changes in parameters associated with tear film stability after instillation of long-acting diquafosol ophthalmic solution in soft contact lens wearers

## TL;DR

This study shows that a long-acting eye drop solution improves tear film stability in soft contact lens wearers for longer periods compared to a standard version.

## Contribution

The study demonstrates the prolonged efficacy of a long-acting diquafosol solution on tear film stability in contact lens users.

## Key findings

- DQS LX improved tear meniscus height for up to 80 minutes and non-invasive tear break-up time for up to 80 minutes when wearing contact lenses.
- Compared to DQS, DQS LX showed significantly higher tear meniscus height and prolonged tear break-up time at multiple time points.
- Ocular surface temperature varied with changes in tear film stability parameters.

## Abstract

To investigate temporal changes in parameters associated with tear film stability after instillation of long-acting 3% diquafosol ophthalmic solution (DQS LX), which contains polyvinylpyrrolidone.

Prospective crossover study design.

We enrolled 23 eyes of 23 soft contact lens (SCL) wearers (aged 25.3 ± 4.4 years). One-day disposable silicone hydrogel lenses (narafilcon A) were used in this study. DQS LX was instilled without a SCL on the first day. On the other two days, subjects received DQS or DQS LX at 7 h after wearing SCLs. Tear meniscus height (TMH), non-invasive tear break-up time (NIBUT) and ocular surface temperature (OST) were measured before and at 5, 15, 30, 45, 60, 80 and 120 min after instillation.

When not wearing SCLs, DQS LX instillation significantly improved TMH for up to 120 min and NIBUT for up to 80 min. When wearing SCLs, DQS and DQS LX instillation significantly increased TMH for up to 45 and 80 min, and NIBUT for up to 15 and 30 min. Compared to DQS, DQS LX administration resulted in a significantly higher TMH at 5, 60 and 80 min, as well as a significantly prolonged NIBUT at 5 and 60 min. OST with and without SCLs also varied depending on the changes in the parameters associated with tear film stability.

Compared to DQS, when wearing SCLs, DQS LX was found to increase the amount of tear fluid and improve tear film stability for longer periods.