# Dopa-responsive parkinsonism without cerebellar ataxia in spinocerebellar ataxia 6

**Authors:** Shun Yoshida, Toshiyuki Takahashi, Naoki Suzuki, Muneshige Tobita

PMC · DOI: 10.1016/j.prdoa.2025.100322 · Clinical Parkinsonism & Related Disorders · 2025-04-02

## TL;DR

This paper reports a rare case of a spinocerebellar ataxia 6 patient with parkinsonism that responded to levodopa, without cerebellar ataxia.

## Contribution

The novelty is the identification of dopa-responsive parkinsonism in an SCA6 patient without typical cerebellar symptoms.

## Key findings

- An SCA6 patient exhibited parkinsonism that improved with levodopa.
- The patient did not show cerebellar ataxia, which is typical in SCA6.
- This case expands the clinical spectrum of SCA6.

## Abstract

•While SCA6 patients mainly show pure cerebellar ataxia, some cases have parkinsonism.•In SCA6 patients, levodopa responsivity to parkinsonism is seldom reported.•We show an SCA6 patient with dopa-responsive parkinsonism without cerebellar ataxia.

While SCA6 patients mainly show pure cerebellar ataxia, some cases have parkinsonism.

In SCA6 patients, levodopa responsivity to parkinsonism is seldom reported.

We show an SCA6 patient with dopa-responsive parkinsonism without cerebellar ataxia.

## Linked entities

- **Chemicals:** levodopa (PubChem CID 6047)
- **Diseases:** spinocerebellar ataxia 6 (MONDO:0008457), cerebellar ataxia (MONDO:0000437)

## Full-text entities

- **Diseases:** Dopa-responsive parkinsonism (MESH:C538007), SCA6 (MESH:D020754), parkinsonism (MESH:D010302), cerebellar ataxia (MESH:D002524)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12002965/full.md

## References

8 references — full list in the complete paper: https://tomesphere.com/paper/PMC12002965/full.md

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Source: https://tomesphere.com/paper/PMC12002965