# Clinical repercussions of statin use during pregnancy: a review of the literature

## TL;DR

This paper reviews the effects of statin use during pregnancy, finding no evidence of fetal malformations but highlighting the need for more research on benefits like pre-eclampsia prevention.

## Contribution

The study provides a focused review of recent literature on statin safety and potential benefits during pregnancy.

## Key findings

- Statin use during pregnancy is not linked to fetal malformations.
- Statin use may help reduce oxidative stress and angiogenic dysfunction.
- Pravastatin is considered safer than other statins for use during pregnancy.

## Abstract

Statins are the most widely used pharmacological class for treating hyperlipidemia, although they are contraindicated during pregnancy. This study aims to demonstrate the clinical effects of statins in pregnant women through an interactive review. Fifteen original articles were selected, in English or Portuguese, within of five years. Statins have not been associated with the development of fetal malformations and their use may be useful in preventing unfavorable cardiovascular outcomes, with the potential to reduce oxidative stress and angiogenic dysfunction. However, the use of statins to prevent pre-eclampsia in humans has not been properly clarified and further studies are needed. Pravastatin is considered safer than statins for use during pregnancy.