# SEOM-GEIS Spanish clinical guidelines for the management of soft‑tissue sarcomas (2024)

## TL;DR

This paper provides updated clinical guidelines for managing soft-tissue sarcomas, emphasizing multidisciplinary care and treatment options based on tumor characteristics.

## Contribution

The paper presents the latest Spanish clinical guidelines for soft-tissue sarcoma management, incorporating current treatment strategies and recommendations.

## Key findings

- Wide surgical resection with clear margins is recommended for localized soft-tissue sarcomas.
- Radiotherapy is advised for large, deep, or high-grade tumors or after incomplete resection.
- Anthracycline-based chemotherapy is the first-line treatment for advanced disease.

## Abstract

Soft-tissue sarcomas are rare, diverse malignant tumors of mesenchymal origin, requiring diagnosis and treatment by a specialized multidisciplinary team. Initial assessment includes radiology and biopsy, followed by wide surgical resection with clear margins for localized cases. Radiotherapy is recommended for large, deep, high-grade tumors or after incomplete resection, while perioperative chemotherapy may be considered for high-risk cases. In oligometastatic disease, combining local and systemic therapies is an option. Anthracycline-based chemotherapy is the first-line treatment in advanced disease, though other drugs show efficacy in certain subtypes. Given the limited options, enrolling in clinical trials is advised for patients needing further treatment.