# Case Report: Primary intracranial high-grade myofibroblastic sarcoma and literature review

## TL;DR

This case report describes the first known instance of a rare aggressive brain tumor called high-grade myofibroblastic sarcoma and its successful treatment with surgery and radiotherapy.

## Contribution

The first reported case of primary intracranial high-grade myofibroblastic sarcoma with long-term recurrence-free survival.

## Key findings

- The patient underwent surgical excision followed by 60 Gy of adjuvant radiotherapy.
- As of November 2024, the patient remained recurrence-free for 24 months.
- This case provides potential evidence for effective treatment strategies for intracranial HGMS.

## Abstract

High-grade myofibroblastic sarcoma (HGMS) is exceedingly rare and highly aggressive, with a poor prognosis. Currently, there is no consensus on its definition. Wide resection is the standard of care for most patients, but clinical data on treatment outcomes remain limited. Here, we present the first reported case of HGMS originating intracranially. Surgical excision of the tumor was performed, followed by adjuvant radiotherapy with a total dose of 60 Gy in 30 fractions. As of November 2024, the patient had achieved 24 months of recurrence-free survival. This case may provide new evidence that could be useful for the treatment of rare primary intracranial HGMS.