# Effective management of pulmonary embolism after initial diagnosis of acute coronary syndrome: a case report highlighting differential diagnosis challenges

**Authors:** Jiahuan Rao, Zhiyan Wang, Haibo Chen

PMC · DOI: 10.3389/fmed.2025.1518628 · Frontiers in Medicine · 2025-04-02

## TL;DR

A case report shows how a patient's symptoms of chest pain were initially thought to be heart-related but were actually due to a blood clot in the lungs.

## Contribution

The case highlights diagnostic challenges and the importance of multidisciplinary management in distinguishing pulmonary embolism from acute coronary syndrome.

## Key findings

- Initial symptoms and tests suggested acute coronary syndrome, but further testing revealed pulmonary embolism.
- Treatment with an IVC filter, thrombus aspiration, and anticoagulation improved patient outcomes.
- The case underscores the need for careful differential diagnosis in patients with overlapping symptoms.

## Abstract

Pulmonary embolism (PE) often presents with symptoms similar to acute coronary syndrome (ACS), making diagnosis challenging. We report a case of a 55-year-old male with hypertension, chronic kidney disease, and hyperuricemia who developed chest pain and shortness of breath. Initial evaluation suggested ACS due to electrocardiogram changes and elevated cardiac biomarkers. However, coronary angiography (CAG) showed no significant stenosis, prompting further diagnostic workup. Computed tomography pulmonary angiography (CTPA) confirmed PE, likely secondary to deep vein thrombosis (DVT) in the right lower extremity. The patient was treated with an inferior vena cava (IVC) filter and thrombus aspiration, followed by anticoagulation therapy. This case highlights the critical need to differentiate PE from ACS and emphasizes the importance of a multidisciplinary approach in managing thromboembolic events to ensure optimal patient outcomes.

## Linked entities

- **Diseases:** pulmonary embolism (MONDO:0005279), acute coronary syndrome (MONDO:0005542), chronic kidney disease (MONDO:0005300), hyperuricemia (MONDO:0002144)

## Full-text entities

- **Diseases:** thrombus (MESH:D013927), thromboembolic (MESH:D013923), shortness of breath (MESH:D004417), chest pain (MESH:D002637), ACS (MESH:D054058), chronic kidney disease (MESH:D051436), PE (MESH:D011655), DVT (MESH:D020246), hypertension (MESH:D006973), hyperuricemia (MESH:D033461)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11999957/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC11999957/full.md

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Source: https://tomesphere.com/paper/PMC11999957