This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
Retraction: Casticin potentiates TRAIL-induced apoptosis of gastric cancer cells through endoplasmic reticulum stress
Abstract
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Taxonomy
TopicsEndoplasmic Reticulum Stress and Disease · Toxin Mechanisms and Immunotoxins · Cell death mechanisms and regulation
After this article [1] was published, concerns were raised regarding results presented in Figs 2 and 4-7.
Specifically:
The authors did not respond to editorial requests for a response and underlying data.
After publication of [1], the BGC-823, SGC-7901, and MGC-803 cell lines reported in [1] were identified as contaminated cell lines and are potential derivatives of HeLa [5–8].
In light of the above unresolved concerns, which undermine the reliability of the reported results and conclusions, the PLOS One Editors retract this article.
All authors either did not respond directly or could not be reached.
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Zhou Y, Tian L, Long L, Quan M, Liu F, Cao J. Casticin potentiates TRAIL-induced apoptosis of gastric cancer cells through endoplasmic reticulum stress. P Lo S One. 2013;8(3): e 58855. doi: 10.1371/journal.pone.0058855 23536831 PMC 3594187 · doi ↗ · pubmed ↗
- 2Chiu S-C, Chen S-P, Huang S-Y, Wang M-J, Lin S-Z, Harn H-J, et al. Induction of apoptosis coupled to endoplasmic reticulum stress in human prostate cancer cells by n-butylidenephthalide. P Lo S One. 2012;7(3): e 33742. doi: 10.1371/journal.pone.0033742 22470469 PMC 3314677 · doi ↗ · pubmed ↗
- 3Sung B, Ravindran J, Prasad S, Pandey MK, Aggarwal BB. Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. J Biol Chem. 2010;285(46): 35418–27. doi: 10.1074/jbc.M 110.172767 20837473 PMC 2975165 · doi ↗ · pubmed ↗
- 4Sung B, Ravindran J, Prasad S, Pandey MK, Aggarwal BB. Gossypol induces death receptor-5 through activation of ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. J Biol Chem. 2016;291(32): 16923. doi: 10.1074/jbc.A 110.172767 27496964 PMC 4974406 · doi ↗ · pubmed ↗
- 5Ye F, Chen C, Qin J, Liu J, Zheng C. Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China. FASEB J. 2015;29(10): 4268–72. doi: 10.1096/fj.14-266718 26116706 · doi ↗ · pubmed ↗
- 6Bian X, Yang Z, Feng H, Sun H, Liu Y. A Combination of species identification and STR profiling identifies cross-contaminated cells from 482 human tumor cell lines. Sci Rep. 2017;7(1):9774. doi: 10.1038/s 41598-017-09660-w 28851942 PMC 5575032 · doi ↗ · pubmed ↗
- 7Cao F, Sun H, Yang Z, Bai Y, Hu X, Hou Y, et al. Multiple approaches revealed M Gc 80-3 as a somatic hybrid with He La cells rather than a gastric cancer cell line. Int J Cancer. 2024;154(1): 155–68. doi: 10.1002/ijc.34677 37543987 · doi ↗ · pubmed ↗
- 8Yang M, He J, Xia S, Wang Y, Xiong J, Liao C, et al. Investigation of the mixed origins of the MGC-803 cell line reveals that it is a hybrid cell line derived from He La. Hum Cell. 2024;37(2): 560–6. doi: 10.1007/s 13577-023-01011-4 38079103 · doi ↗ · pubmed ↗