# Histamine Intolerance: An Overlooked Diagnosis of Recurrent Anaphylaxis-Like Symptoms

## TL;DR

Histamine intolerance can cause recurring anaphylaxis-like symptoms after eating seafood and can be managed with diet and medication.

## Contribution

The paper presents a case confirming histamine intolerance as a cause of recurrent anaphylaxis-like symptoms and highlights its proper management.

## Key findings

- A 26-year-old male had recurrent anaphylaxis-like symptoms after seafood consumption.
- Histamine intolerance was diagnosed using a detailed history and a histamine 50-skin-prick test.
- Symptoms were resolved with a low-histamine diet and antihistamine medication.

## Abstract

Histamine intolerance is a common disorder associated with an impaired histamine metabolism. It should be considered in individuals with sporadic or repeated anaphylaxis-like symptoms after seafood consumption. We encountered a 26-year-old male patient who experienced recurrent episodes of anaphylaxis-like symptoms after ingesting seafood. A detailed history-taking and a histamine 50-skin-prick test confirmed the diagnosis of histamine intolerance. In addition, a low-histamine diet and prophylactic antihistamine medication did not result in symptom recurrence. Proper management of histamine intolerance can improve the individual's quality of life.