# Nutraceutical supplement slim reshaped colon histomorphology and reduces Mucispirillum schaedleri in obese mice

## TL;DR

A nutraceutical supplement improved gut health and reduced harmful bacteria in obese mice.

## Contribution

The study introduces a nutraceutical supplement with a duplibiotic effect to reshape gut microbiota in obesity.

## Key findings

- Slim improved lipid metabolism and colon histomorphology in obese mice.
- Supplementation reduced Mucispirillum schaedleri levels linked to triglycerides and VLDL-c.
- The effects are attributed to synergistic bioactive compounds in the supplement.

## Abstract

Bioactive compounds and whole foods have emerged as promising interventions to address gut microbiota dysbiosis linked to obesity. Compounds such as berberine and coenzyme Q10 are well-recognized for their roles in managing metabolic syndrome and exerting antioxidant effects, while beet pulp, rich in fiber and antioxidants, enhances gut health through additional prebiotic benefits.

This study evaluated the effects of a nutraceutical supplement, Slim, on the modulation of gut microbiota in obese mice induced by a high-fat diet.

Our results demonstrated that Slim supplementation significantly improved lipid metabolism, reshaped colon histomorphology, and decreased levels of Mucispirillum schaedleri, which were correlated with VLDL-c and triglycerides.

We suggest these effects are driven by a duplibiotic effect, resulting from the synergistic action of the bioactive compounds.