# Does ozone gel enhance the bone width and buccal plate of bone thickness surrounding the implant following osseodensification? A randomized controlled clinical trial

## TL;DR

This clinical trial investigated whether ozone gel improves bone dimensions after a sinus lift procedure, but found no significant differences compared to a control group.

## Contribution

The study introduces a novel application of ozone gel in transcrestal sinus elevation and evaluates its impact on bone width and thickness.

## Key findings

- Ozone gel did not significantly increase bone width compared to the control group (8.96 mm vs. 8.54 mm).
- No significant difference in labial plate thickness was observed between the ozone gel and control groups (1.89 mm vs. 1.86 mm).
- Both groups produced acceptable outcomes, though ozone gel showed slightly better but non-significant results.

## Abstract

The present study was conducted to evaluate the effect of using ozone gel with transcrestal sinus elevation using osteotomes, on the bone width and the buccal plate of bone thickness around the implants placed simultaneously.

A total of 30 sinuses with an average residual alveolar bone height ranging from 4–7 mm participated in this randomized controlled clinical trial. Following a closed sinus lift procedure, patients were randomized into two groups: one for the ozone gel recipient group and the other for control group. Cone beam computed tomography was carried out both immediately and four months postoperatively. Radiographic evaluations were performed to assess bone width and labial plate thickness at both crestal and midcrestal levels.

Radiographic analysis revealed that the mean bone width of the control group after four months postoperative was (8.54 ± 1.46 mm) compared to (8.96 ± 1.66 mm) in the study group, which was statistically insignificant (P ≤ .0.05). The mean labial plate of bone thickness value of the control group after four months postoperative was (1.86 ± 0.63 mm) compared to (1.89 ± 0.51 mm) in the study group. Although the bone dimensions in the study group was higher than the control group, it was statistically insignificant (P ≤ .0.05).

When compared to the graftless group, the ozone gel recipient group showed non-significant difference in the results in terms of bone width and thickness. Both methods, nevertheless, produced outcomes that were acceptable.

This study protocol was retrospectively registered on the trial registry “Clinical trials.gov PRS”. ClinicalTrials.gov ID is: NCT06604819 and the registration date is 20/9/2024.

The online version contains supplementary material available at 10.1007/s10006-025-01367-x.