# Vps34 puts the ‘e’ in eTreg cells **Authors:** Ruchi Saxena, You-Wen He PMC · DOI: 10.1371/journal.pbio.3003109 · PLOS Biology · 2025-04-14 ## TL;DR This study identifies Vps34 as a key regulator in the development and maintenance of effector regulatory T cells. ## Contribution The study reveals Vps34 as a master regulator of effector Treg cell heterogeneity. ## Key findings - Vps34 is shown to drive the generation of effector Treg cells. - Vps34 is essential for maintaining effector Treg cell function. ## Abstract Regulatory T cells (Tregs) exist in distinct subsets, but key regulators of their heterogeneity remain unclear. A recent PLOS Biology study shows that the class III PI3K Vps34 acts as a master orchestrator, driving effector Treg generation and maintenance. ## Linked entities - **Genes:** PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3) [NCBI Gene 5289] ## Full-text entities - **Genes:** PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3) [NCBI Gene 5289] {aka VPS34, Vps34, hVps34} ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC11996072/full.md ## Figures 1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11996072/full.md ## References 10 references — full list in the complete paper: https://tomesphere.com/paper/PMC11996072/full.md --- Source: https://tomesphere.com/paper/PMC11996072