# Neutrophil-related IL1R2 gene predicts the occurrence and early progression of myocardial infarction

## TL;DR

This study identifies the IL1R2 gene as a potential marker for predicting heart attacks and their early progression, linked to neutrophil activity.

## Contribution

The study introduces IL1R2 as a novel neutrophil-related gene marker for early myocardial infarction diagnosis and progression.

## Key findings

- Neutrophils are key immune cells involved in the onset of myocardial infarction.
- A diagnostic panel with five neutrophil-related genes achieved high accuracy (AUC = 0.887).
- IL1R2 was confirmed to be associated with the early phase of MI in mouse models.

## Abstract

Myocardial infarction (MI) is a leading cause of death worldwide. Immune cells play a significant role in the MI development. This study aims to identify a marker related to neutrophil for the diagnosis and early progression of MI.

Key genes were screened using three machine learning algorithms to establish a diagnostic model. A gene associated with the early progression of MI was identified based on single cell RNA sequencing data. To further validate the predictive value of the gene, the mouse models of MI were constructed. Immunofluorescence (IF) analysis demonstrated the co-expression of the gene with neutrophils. Immunohistochemistry (IHC) was performed to validate the role of the gene in the progression of MI.

Neutrophils were identified and verified as the key infiltrating immune cells (IICs) involved in the onset of MI. A diagnostic panel with superior performance was developed using five key genes related to neutrophils in MI (AUC = 0.887). Among the panel, IL1R2 was found to early phase of MI, which was further corroborated by IHC in mouse models of MI.

This study suggests that IL1R2, which is specific to neutrophils, can predict the diagnosis and early progression of MI, providing new insights into the clinical management of MI.