# Laryngeal sarcomatoid carcinoma: a case report and literature review on potential molecular targets for therapeutic opportunities

## TL;DR

This paper reports a case of laryngeal sarcomatoid carcinoma and reviews potential molecular targets for better treatment and diagnosis.

## Contribution

The study identifies possible molecular targets for therapeutic opportunities in laryngeal sarcomatoid carcinoma.

## Key findings

- LSC is an aggressive malignancy with poor prognosis, predominantly in older males.
- Molecular understanding may lead to improved targeted therapies and early diagnosis for LSC.
- A case study is presented to support the need for better therapeutic options and prognostic markers.

## Abstract

Laryngeal sarcomatoid carcinoma (LSC) is a rare variant of laryngeal malignancies characterized by an aggressive nature and poor prognosis, predominantly affecting older males. Although early diagnosis may facilitate organ preservation through adjuvant chemotherapy and radiation therapy, advanced stages of the disease, as classified by the TNM system, necessitate a deeper understanding of molecular interactions. This understanding could potentially yield improved molecularly targeted therapeutic opportunities and early diagnosis that likely support the treatment benefits in the LSC. Therefore, this study aims to identify possible molecular targets in LSC to better inform therapeutic options and prognostic markers for obtaining treatment benefits, alongside presenting a case study of a patient with LSC who was admitted to our department.