# Boiled Sausage Sign: A Novel MRI Marker for Identifying Subacute Secondary Hydrocephalus in the Elderly

**Authors:** Miharuka Yokosaki, Shuichiro Neshige, Hirofumi Maruyama

PMC · DOI: 10.7759/cureus.80587 · Cureus · 2025-03-14

## TL;DR

This case report introduces a new MRI marker, the 'boiled sausage sign,' to help identify subacute secondary hydrocephalus in elderly patients.

## Contribution

The paper introduces the 'boiled sausage sign' as a novel MRI marker for subacute secondary hydrocephalus.

## Key findings

- MRI showed uniform ventricular enlargement resembling a 'boiled sausage' in a patient with secondary hydrocephalus.
- The sign can help differentiate secondary hydrocephalus from brain atrophy even when the Evans index is normal.
- The case involved meningeal carcinomatosis from nasal cavity melanoma causing hydrocephalus.

## Abstract

Ventricular enlargement is commonly caused by brain atrophy or hydrocephalus; however, distinguishing between these conditions in elderly patients is often challenging. This case report describes a patient in whom secondary hydrocephalus was suspected based on characteristic findings of ventricular enlargement, leading to the final diagnosis. A 75-year-old man with nasal cavity malignant melanoma, treated with nivolumab for six months, presented with three weeks of progressive lethargy and anorexia and subsequent mild confusion. Although MRI-negative encephalitis related to nivolumab was initially suspected, mild ventricular enlargement with a uniformly dilated anterior horn shape resembling a "boiled sausage" was noted. Subsequent gadolinium-enhanced MRI demonstrated diffuse dural thickening contiguous with the nasal cavity and meningeal enhancement, leading to the final diagnosis of intracranial invasion of malignant melanoma with secondary hydrocephalus due to meningeal carcinomatosis. Subacute hydrocephalus manifests as a uniform ventricular enlargement on MRI, a finding we propose as the novel "boiled sausage sign." This sign may help distinguish secondary hydrocephalus from physiologic atrophy, even when the Evans index remains within the normal range.

## Linked entities

- **Diseases:** malignant melanoma (MONDO:0005105), hydrocephalus (MONDO:0001150), encephalitis (MONDO:0019956), meningeal carcinomatosis (MONDO:0700219)

## Full-text entities

- **Diseases:** meningeal carcinomatosis (MESH:D055756), anorexia (MESH:D000855), lethargy (MESH:D053609), Secondary Hydrocephalus (MESH:D006849), brain atrophy (MESH:C566985), confusion (MESH:D003221), Ventricular enlargement (MESH:D006332), encephalitis (MESH:D004660), atrophy (MESH:D001284), malignant melanoma (MESH:D008545)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11994363/full.md

## References

10 references — full list in the complete paper: https://tomesphere.com/paper/PMC11994363/full.md

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Source: https://tomesphere.com/paper/PMC11994363