# Cytotoxicity and molecular docking analysis of phytochemicals from Vallisneria spiralis with protein target 3CZH in breast cancer management

## TL;DR

This study explores the potential of Vallisneria spiralis in managing breast cancer through cytotoxicity and molecular docking analysis with a specific protein target.

## Contribution

The study introduces the cytotoxic and antioxidant effects of Vallisneria spiralis nanoparticles and their phytochemicals docking with protein 3CZH for breast cancer.

## Key findings

- Higher concentrations of Vallisneria spiralis nanoparticles increased cytotoxicity against MCF-7 breast cancer cells.
- Phytochemicals from Vallisneria spiralis showed optimal binding features with the target protein 3CZH.
- The plant's antioxidant potential was confirmed using the DPPH radical scavenging assay.

## Abstract

The anticancer potential of Vallisneria spiralis Linnaeus (Vallisneria spiralis L.) for human
breast cancer management is of interest. In vitro shows that increasing concentrations of Vallisneria spiralis
silver nanoparticles (AgNPs) and iron oxide nanoparticles (IONPs) resulted in greater cytotoxicity against MCF-7 breast cancer cells.
The antioxidant potential of Vallisneria spiralis L. was assessed using 2-diphenyl-1-picryl-hydroxyl (DPPH) radical
scavenging assay. Further molecular docking analysis of phytocompounds from Vallisneria spiralis L. with the target
protein (PDB ID: 3CZH) shows optimal binding features. Thus, cytotoxicity analysis of Vallisneria spiralis for breast
cancer with molecular docking of its phytochemicals and a target protein 3CZH is reported for further consideration.