# Linking platelet indices and uterine artery Doppler parameters for preeclampsia prediction and its severity

## TL;DR

This study explores how platelet indices and uterine artery Doppler measurements can help predict preeclampsia and its severity during pregnancy.

## Contribution

The study identifies a combination of platelet indices and Doppler parameters as a novel predictor for early-onset and severe preeclampsia.

## Key findings

- Platelet count, mean platelet volume, and platelet/lymphocyte ratio were significant predictors of preeclampsia.
- Uterine artery Doppler pulsatility index was also significant in predicting preeclampsia.
- Combining these indices improved sensitivity for predicting severe and early-onset preeclampsia.

## Abstract

Preeclampsia is one of the most common medical complications of pregnancy and the second largest cause of maternal and fetal
mortality and morbidity. Preeclampsia is a multi-systemic hypertension condition with an unknown cause. A Prospective Observational
Study was conducted on antenatal women with gestation age of 11 to 13+6 weeks. Participants underwent routine investigations including
Platelet Indices and Uterine Artery Ultrasonography Doppler. Selected patients were specifically evaluated at 22-24 weeks, 31-34 weeks and >36
weeks until delivery along with routine antenatal care visits. Among the platelet indices, the platelet Count, Mean Platelet volume (MPV),
Platelet/Lymphocyte ratio were found significant and among Uterine Artery Doppler Parameters- Pulsatility Index was found significant in
prediction of preeclampsia. The Combination of platelet indices and uterine artery doppler parameters showed better sensitivity in
prediction of early onset and severe form of preeclampsia can be incorporated into routine prenatal care using the existing
infrastructure can be used in the prediction and early diagnosis of preeclampsia.