# Analysis of protein interaction network in obesity linked with periodontitis

## TL;DR

This study explores how proteins in saliva may connect obesity and periodontitis, suggesting a biological link between the two conditions.

## Contribution

The novel contribution is identifying a protein interaction network linking obesity and periodontitis using proteomic data.

## Key findings

- A PPI network with significant interactions was found between obesity and periodontitis-related proteins.
- Twenty proteins were identified with roles in biological functions linked to both conditions.
- The study suggests a biological mechanism for the interaction between obesity and periodontitis.

## Abstract

The clinical link between obesity and periodontitis by investigating the potential interaction among proteins is of interest. A
protein-protein interaction (PPI) network analysis using STRING was conducted on novel proteins identified from saliva samples through
quantitative proteomics and mass spectrometry. Twenty proteins were involved in molecular process, cellular components and biological
functions focusing on proteins with variants closely associated with obesity and periodontitis. Analysis revealed that PPI network
exhibited a high degree of interactions, indicating a biological connection with a significant p value 4.8*105. These PPIs discuss the
interplay between obesity and periodontitis, require further experimental validation, unravel new clues for downstream studies and
propose biological mechanisms through which these two conditions may interact.