# Cannabis and Polypharmacy Leading to Hospitalization for Acute Confusion and Inability to Ambulate

## TL;DR

A patient's hospitalization for mobility issues was linked to cannabis use and gabapentin, highlighting a possible interaction.

## Contribution

The case highlights a novel association between THC use, gabapentin, and acute functional decline.

## Key findings

- The patient's acute decline in mobility coincided with THC use and gabapentin initiation.
- Polypharmacy and cannabis use may contribute to hospitalization for acute confusion and immobility.

## Abstract

Inability to ambulate is a common issue for which an Emergency Department (ED) may request inpatient admission to the hospital. Frequent contributing factors include advanced age, spinal stenosis, osteoarthritis, deconditioning, and polypharmacy. We present an interesting case of a patient admitted due to inability to ambulate who had a significant acute decline in function coincident with the introduction of gabapentin in the setting of heavy tetrahydrocannabinol (THC) use.