# Association Between Lupus Nephritis and Renal Clear-Cell Carcinoma: A Case Report and Review of the Literature

## TL;DR

A young woman was diagnosed with both lupus nephritis and kidney cancer, highlighting the need for careful monitoring and combined treatment approaches.

## Contribution

This case report is one of the few to document the co-occurrence of lupus nephritis and renal cell carcinoma.

## Key findings

- A patient had both lupus nephritis and renal clear-cell carcinoma diagnosed at the same time.
- The patient improved after partial nephrectomy and immunosuppressive therapy.
- The case emphasizes the need for multidisciplinary care in complex lupus-related conditions.

## Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease affecting several organs, including the kidneys, potentially leading to lupus nephritis (LN). SLE has also been associated with several neoplasias, but its relation to renal cell carcinoma (RCC) has been little explored. We report a young women diagnosed concomitantly with LN and RCC. The latter was discovered incidentally during an investigation of nephrotic syndrome and confirmed on histology and renal microscopy. The patient was submitted to partial nephrectomy and immunosuppression, with good outcome, as shown by the improvement in proteinuria and other symptoms. Our case highlights the complexity of diagnosing SLE in combination with RCC and the importance of permanent surveillance and multidisciplinary approach to optimize treatment.