The Antiproliferative Activity and NO Inhibition of Neo-Clerodane Diterpenoids from Salvia guevarae in RAW 264.7 Macrophages
Juan Pablo Torres-Médicis, Celia Bustos-Brito, Leovigildo Quijano, Brenda Y. Bedolla-García, Sergio Zamudio, Teresa Ramírez-Apan, Diego Martínez-Otero, Baldomero Esquivel
TL;DR
This study identifies new diterpenoids from Salvia guevarae and tests their antiproliferative and NO inhibition effects in macrophages.
Contribution
The discovery of six new neo-clerodane diterpenoids and their antiproliferative and NO inhibition activities in macrophages.
Findings
Six new neo-clerodane diterpenoids were isolated from Salvia guevarae.
Compounds 2 and 7 showed moderate antiproliferative activity against K562 cells.
Three compounds exhibited significant NO inhibition in RAW 264.7 macrophages.
Abstract
In this study, nine neo-clerodane-type diterpenoids (1–9) were isolated from the dichloromethane extract of Salvia guevarae Bedolla & Zamudio leaves. Compounds 1–6 were new natural products, and 7–9 were acetone artifacts. In addition, four neo-clerodanes diterpenoids (10–13) previously described from different sources and six triterpenoids—identified as 3β,20,25-trihydroxylupane, oleanolic acid, 3β-O-acetyl-oleanolic acid, ursolic acid, 3β-O-acetyl-betulinic acid, and 3β,28-O-diacetyl-betulin—were isolated. Additionally, five flavonoids were also isolated from the methanol extract: quercetin-3-O-β-xylopyranosyl-(1 → 2)-β-galactopyranoside, taxifolin-7-O-β-glucopyranoside, naringenin-7-O-β-glucopyranoside, a mixture of 2R and 2S eriodictyol-7-O-β-glucopyranoside, caffeic acid, the methyl ester of rosmarinic acid, and rosmarinic acid. The structure of the isolated compounds was…
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Taxonomy
TopicsNatural product bioactivities and synthesis · Phytochemistry and Biological Activities · Essential Oils and Antimicrobial Activity