# Central Nervous System Metastases in Endometrial Carcinoma: A Case Series

## TL;DR

This paper reports three rare cases of endometrial cancer spreading to the brain, highlighting the need for early brain imaging in such patients.

## Contribution

The novelty lies in documenting rare CNS metastases from endometrial carcinoma through a series of distinct clinical cases.

## Key findings

- Endometrial carcinoma can metastasize to the central nervous system, even years after initial diagnosis.
- Brain metastases should be considered in patients with endometrial cancer presenting new neurological symptoms.
- Early brain imaging is recommended for patients with endometrial cancer to detect potential metastases.

## Abstract

Central nervous system metastases from endometrial carcinoma are a rare occurrence and suggest that metastatic endometrial carcinoma can have variable presentations. In this case report, we present three separate cases of patients diagnosed with endometrial carcinoma with metastasis to the central nervous system. The first case presents a woman with grade 2 endometrioid adenocarcinoma with mucinous and clear cell features found later to have skull metastasis with extradural extension. The second case presents a patient with an endometrial yolk sac tumor who, years after her primary diagnosis, was found to have metastasis to the brain. The final case is a woman with endometrial adenocarcinoma who developed brain metastases. While rare, it is important to consider the possibility of the presence of distal bone and brain metastases in patients with endometrial carcinoma. Special attention must be given when these patients report new neurologic symptoms, and one must consider early brain imaging.