# A Case Report of Intraoral Injection of Botulinum Toxin A for Trigeminal Neuralgia: A Rare but Safe Intervention

**Authors:** Richard F Radlberger, Stefan Leis

PMC · DOI: 10.7759/cureus.80456 · Cureus · 2025-03-12

## TL;DR

This case report describes a rare but safe use of intraoral botulinum toxin A injections for treating trigeminal neuralgia in an elderly woman.

## Contribution

The paper presents a novel intraoral injection approach as a safe addition to standard subcutaneous botulinum toxin A therapy for trigeminal neuralgia.

## Key findings

- The patient responded well to intraoral botulinum toxin A injections.
- Combining intraoral and subcutaneous injections improved trigeminal neuralgia symptoms.
- The intervention was found to be safe in an elderly patient.

## Abstract

Although off-label, according to the recommendations from guidelines, subcutaneous injections with botulinum toxin A in a follow-the-pain pattern are increasingly being used in trigeminal neuralgia. Subsequently, we report on an elderly woman with trigeminal neuralgia who responded well to intraoral therapy in addition to the subcutaneous injections in the dermal area of the affected trigeminal branch.

## Linked entities

- **Diseases:** trigeminal neuralgia (MONDO:0008599)

## Full-text entities

- **Diseases:** pain (MESH:D010146), Trigeminal Neuralgia (MESH:D014277)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11987049/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC11987049/full.md

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Source: https://tomesphere.com/paper/PMC11987049