This paper is marked retracted in the scholarly record (OpenAlex). Interpret its findings with caution.
RETRACTION: LncRNA TUG1 Relieves Renal Mesangial Cell Injury by Modulating the miR‐153‐3p/Bcl‐2 Axis in Lupus Nephritis
TL;DR
This retracted study claimed that a long non-coding RNA (TUG1) protects kidney cells in lupus nephritis by regulating miR-153-3p and Bcl-2, but the data was found to be compromised.
Contribution
The study proposed a novel mechanism involving TUG1, miR-153-3p, and Bcl-2 in protecting mesangial cells from injury in lupus nephritis.
Findings
TUG1 was suggested to modulate miR-153-3p levels in mesangial cells.
The miR-153-3p/Bcl-2 axis was implicated in cell injury in lupus nephritis.
Findings were retracted due to duplicated data in a figure.
Abstract
RETRACTION: L. Liu, Y. Zhang and L. Zhong, “LncRNA TUG1 Relieves Renal Mesangial Cell Injury by Modulating the miR‐153‐3p/Bcl‐2 Axis in Lupus Nephritis,” Immunity, Inflammation and Disease 11, no. 4 (2023): e811, https://doi.org/10.1002/iid3.811. The above article, published online on 12 April 2023 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief, Marc Veldhoen; and John Wiley & Sons Ltd. The retraction has been agreed upon following an investigation into concerns raised by a third party. The investigation revealed that the LPS+miR‐153‐3p inhibitor flow cytometry plot presented in Figure 6B has been found duplicated in another article by a different author group representing different scientific conditions. The authors provided an explanation and some data but this was not deemed sufficient. The editors have lost…
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Taxonomy
TopicsCancer-related molecular mechanisms research · Circular RNAs in diseases · Systemic Lupus Erythematosus Research
RETRACTION: L. Liu, Y. Zhang and L. Zhong, “LncRNA TUG1 Relieves Renal Mesangial Cell Injury by Modulating the miR‐153‐3p/Bcl‐2 Axis in Lupus Nephritis,” Immunity, Inflammation and Disease 11, no. 4 (2023): e811, https://doi.org/10.1002/iid3.811.
The above article, published online on 12 April 2023 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief, Marc Veldhoen; and John Wiley & Sons Ltd. The retraction has been agreed upon following an investigation into concerns raised by a third party. The investigation revealed that the LPS+miR‐153‐3p inhibitor flow cytometry plot presented in Figure 6B has been found duplicated in another article by a different author group representing different scientific conditions. The authors provided an explanation and some data but this was not deemed sufficient. The editors have lost confidence in the data presented and consider the conclusions to be compromised. The authors disagree with the retraction.