# Autophagy-deficient budding yeast cells are sensitive to freeze-thaw stress

## TL;DR

This study shows that yeast cells without autophagy are more vulnerable to freeze-thaw stress, highlighting a new role for autophagy in stress survival.

## Contribution

The study reveals that autophagy is crucial for yeast survival under freeze-thaw stress, a previously unexplored stress condition.

## Key findings

- Autophagy-deficient yeast cells show increased sensitivity to freeze-thaw stress.
- Wild type yeast cells survive freeze-thaw stress better than atg1Δ and atg5Δ mutants.

## Abstract

Autophagy enables eukaryotes to recycle damaged and unneeded materials to ensure survival in times of stress such as starvation. However, the full range of cellular stress responses that activate and require autophagy remains unknown. This study has compared the survival of wild type,
atg1Δ,
and
atg5Δ
budding yeast cells following freeze-thaw stress. The results indicate that cells deficient in autophagy exhibit enhanced sensitivity to freeze-thaw stress.