# Bibliometric analysis and description of research trends on nutritional management in Alzheimer’s disease patients (1988–2024)

## TL;DR

This study maps research trends in nutritional approaches for Alzheimer's disease from 1988 to 2024, highlighting growth and key themes.

## Contribution

The first bibliometric summary of nutritional management research trends in Alzheimer’s disease.

## Key findings

- The number of publications on nutritional management for Alzheimer’s disease has increased annually since 1988.
- Research trends shifted from 'precursor protein' to 'insulin resistance' and 'synaptic plasticity' over time.
- The most cited article focused on the role of diet in providing antioxidants to combat oxidative stress in neurodegenerative diseases.

## Abstract

Alzheimer’s disease (AD) is a severe neurodegenerative disorder. Nutritional management has been recognized as a potential therapeutic approach to mitigate AD progression. This study aimed to analyze the bibliometric characteristics and research trends of publications on nutritional management in AD.

A systematic search was conducted on the Web of Science Core Collection database to identify publications related to nutritional management in AD from 1988 to 2024. Bibliometric analysis was performed using VOSviewers (V 1.6.20), CiteSpace (V 6.3.R1) and R 4.3.3.

A total of 554 publications from 311 countries led by the USA were identified. The number of publications has increased annually. The most cited article discussed the role of diet in providing antioxidants to combat oxidative stress in neurodegenerative diseases. The University of California system published the most articles, and Rush University had the most international collaborations. These publications came from 3,298 authors, among which Mattson MP had the highest total publications and citations. The Journal of Alzheimer’s Disease published the most articles and received the most citations. Keywords analysis revealed evolving trends, with early emphasis on “precursor protein” and later shifts to “dietary restriction,” and more recently, “insulin resistance” and “synaptic plasticity.” Emerging keywords include “obesity,” “cognitive impairment” and “association.”

This study represents the first summary of research trends in AD nutritional management. Future research is likely to focus on the associations between nutrition, insulin resistance, synaptic plasticity, and cognitive impairment in AD patients. This information provides valuable insights for scholars and practitioners in the field.