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Zhidi Lin, Guangyu Xu, Xiao Lu, Hongli Wang, Feizhou Lu, Xinlei Xia, Jian Song, Jianyuan Jiang, Xiaosheng Ma, Fei Zou
TL;DR
This study shows how Piezo1 worsens cartilage degeneration through mitochondrial fission during inflammation.
Contribution
The novel finding is that Piezo1 promotes cartilage degeneration via the Ca2+/CaMKII/Drp1 pathway.
Findings
Piezo1 activation increases mitochondrial fission in cartilage under inflammation.
Blocking Piezo1 reduces cartilage degeneration in mouse models.
The Ca2+/CaMKII/Drp1 axis is identified as a key pathway in this process.
Abstract
The cover image is based on the article Piezo1 exacerbates inflammation‐induced cartilaginous endplate degeneration by activating mitochondrial fission via the Ca2+/CaMKII/Drp1 axis by Zhidi Lin et al., https://doi.org/10.1111/acel.14440.
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Taxonomy
TopicsErythrocyte Function and Pathophysiology · MicroRNA in disease regulation · Bone Metabolism and Diseases