# The rodent aging interventions database (RAID): a data visualization tool for all studies reporting rodent lifespan extension

## TL;DR

The Rodent Aging Interventions Database (RAID) is a tool that collects and visualizes data on interventions that extend the lifespan of mice and rats.

## Contribution

RAID is a novel database and visualization tool that aggregates lifespan extension studies in rodents to guide future research.

## Key findings

- RAID includes data from 121 studies and 212 intervention protocols that extended rodent lifespan.
- The database is publicly accessible and will be periodically updated with new studies.
- The tool allows users to filter and visualize data from rodent aging interventions.

## Abstract

Numerous studies have investigated the effects of various interventions on the lifespans of mice and rats. The design of future rodent lifespan extension experiments might consider experimental parameters used in earlier investigations, but finding and reviewing all previous experiments requires a substantial resource investment. Additionally, when studied collectively, the results of previous investigations might suggest fundamental mechanisms causing age-related degeneration. Here, we report our efforts to find and aggregate data from all research reports of lifespan extension in mice or rats, which we call the “Rodent Aging Interventions Database” (RAID). We identified studies for inclusion using complex PubMed queries and by nomination from our colleagues in the field. The relevant data from each study was manually extracted and recorded in a table. A publicly available, web-based software tool was then created to enable users to visualize and filter this data in a convenient manner. Our current dataset, covering publications up to October 2022, includes 121 unique studies reporting on 212 distinct intervention protocols that extended lifespan in mice or rats. We intend to periodically update our dataset as new rodent lifespan studies are reported. RAID is publicly available at https://levf.org/raid.