# Complete genome and transcriptome of Mycobacterium bovis 3488, a clinical isolate with a novel deletion at the RD1 locus

**Authors:** Jordy Smith, Maria Manou, Joshua Milgram, Seamus Hoey, Susan Warde, Barbara Kirby, Stephen V. Gordon, Kevin Kenny, Pamela A. Kelly

PMC · DOI: 10.1128/mra.00837-24 · Microbiology Resource Announcements · 2025-03-10

## TL;DR

This paper reports the genome and transcriptome of a Mycobacterium bovis strain with a unique deletion in the RD1 locus, which is important for virulence.

## Contribution

The study identifies a novel 14.2 kb deletion in the RD1 locus of a clinical Mycobacterium bovis isolate.

## Key findings

- The isolate Mycobacterium bovis 3488 has a deletion encompassing the RD1 locus.
- Genome and transcriptome data were generated for this clinical isolate.

## Abstract

In members of the Mycobacterium tuberculosis complex, the RD1 locus encodes a type VII secretion system involved in virulence. Herein, we describe the genome and transcriptomic analysis of Mycobacterium bovis 3488, a clinical isolate from a cat, with a 14.2 kb deletion that encompasses the RD1 locus.

## Linked entities

- **Species:** Mycobacterium tuberculosis (taxon 1773)

## Full-text entities

- **Species:** Felis catus (cat, species) [taxon 9685], Mycobacterium tuberculosis (species) [taxon 1773]

## Full text

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## Figures

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## References

33 references — full list in the complete paper: https://tomesphere.com/paper/PMC11984153/full.md

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Source: https://tomesphere.com/paper/PMC11984153