# Transcriptome of brain-like endothelial cells following coxsackievirus B3 infection

## TL;DR

This study examines how brain-like endothelial cells respond at the genetic level when infected by coxsackievirus B3, a virus linked to meningitis.

## Contribution

The study provides a new transcriptomic profile of brain-like endothelial cells infected with coxsackievirus B3.

## Key findings

- The global transcriptome of brain-like endothelial cells was analyzed during coxsackievirus B3 infection.
- The study reveals gene expression changes in endothelial cells interacting with the virus.
- Findings may help understand how the virus disrupts the blood-brain barrier.

## Abstract

Coxsackievirus B3 is a leading cause of viral aseptic meningitis. To gain entry to the central nervous system, it must interact with and disrupt the brain endothelial cells of the blood-brain barrier. Here, we report the global transcriptome of stem-cell-derived brain-like endothelial cells during coxsackievirus B3 infection.