# Interactome of the oncogenic ΔNp73α isoform in human papillomavirus 38 E6/E7-transformed keratinocytes

## TL;DR

This study identifies proteins that interact with ΔNp73α, an oncogenic form of p73, in HPV38-transformed skin cells linked to non-melanoma skin cancer.

## Contribution

The paper presents the first interactome of ΔNp73α in HPV38 E6/E7-transformed keratinocytes.

## Key findings

- ΔNp73α interacts with multiple proteins in both organelle and cytoplasmic compartments.
- The interactome includes proteins involved in cell survival and proliferation pathways.
- Findings highlight potential therapeutic targets in HPV-related skin cancer.

## Abstract

ΔNp73α is a major oncogenic isoform of tumor suppressor p73. Here, we report ΔNp73α protein-binding partners in the organelle and cytoplasmic compartments of a cellular model consisting of human keratinocytes transformed by the E6 and E7 oncoproteins of the β-HPV38 virus associated with non-melanoma skin cancer.