# Draft genomes of six methicillin-resistant Staphylococcus aureus in a Philippine tertiary hospital with insights on putative antimicrobial and phage resistance mechanisms **Authors:** Mark B. Carascal, Jo-Eliz M. Gonzales, Ma. Mona Joy T. Tañedo, Donna May D. Papa, Raul V. Destura, Karl Evans R. Henson PMC · DOI: 10.1128/mra.00097-25 · Microbiology Resource Announcements · 2025-02-25 ## TL;DR This study sequenced six MRSA genomes from a Philippine hospital and identified antibiotic and phage resistance traits. ## Contribution The study provides new insights into MRSA genotypes and their resistance mechanisms in a Philippine hospital setting. ## Key findings - Six MRSA strains were classified into distinct genotypes with SCCmec and spa types. - All strains carried antibiotic resistance genes and antiphage systems. - Findings may help improve MRSA infection control strategies. ## Abstract The genomes of six methicillin-resistant Staphylococcus aureus (MRSA) revealed CC5(ST5)-SCCmec-IVc-spa-t105-PVL+ (n = 3), CC5(ST6)-SCCmec-IVc-spa-t10002 (n = 1), CC5(ST5)-SCCmec-IVa-spa-t002 (n = 1), and CC8(ST8)-SCCmec-IVa-spa-t008-PVL+ (n = 1) genotypes. All possessed multiple antibiotic resistance genes (putative mecA and blaZ, and dfrG for cotrimoxazole-resistant strains), intact staphylococcal prophages, and putative antiphage systems. The results could aid in MRSA infection management and control. ## Linked entities - **Genes:** mecA (adaptor protein controlling oligomerization of the AAA+ protein ClpC) [NCBI Gene 936406], blaZ (penicillin-hydrolyzing class A beta-lactamase BlaZ) [NCBI Gene 48886948], dfrG (trimethoprim-resistant dihydrofolate reductase DfrG) [NCBI Gene 67042568] - **Diseases:** MRSA (MONDO:0100073) - **Species:** Staphylococcus aureus (taxon 1280) ## Full-text entities - **Genes:** blaZ [NCBI Gene 13874473] - **Diseases:** MRSA infection (MESH:D013203) - **Chemicals:** cotrimoxazole (MESH:D015662), methicillin (MESH:D008712) - **Species:** Phaeobacter inhibens (species) [taxon 221822], Staphylococcus aureus (species) [taxon 1280] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC11984118/full.md ## References 14 references — full list in the complete paper: https://tomesphere.com/paper/PMC11984118/full.md --- Source: https://tomesphere.com/paper/PMC11984118