# Safety and efficacy of a feed additive consisting of capsaicin for all animal species (XP Chemistries AB)

**Authors:** Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Ilen Röhe, Katerina Theodoridou, Maria Bastos, Georges Bories, Paul Brantom, Jürgen Gropp, Ruud Woutersen, Jaume Galobart, Paola Manini, Fabiola Pizzo, Maria Vittoria Vettori, Andrew Chesson

PMC · DOI: 10.2903/j.efsa.2025.9340 · EFSA Journal · 2025-04-10

## TL;DR

This paper evaluates the safety and effectiveness of capsaicin as a flavoring feed additive for all animal species.

## Contribution

The study provides a comprehensive safety and efficacy assessment of capsaicin for use in animal feed across various species.

## Key findings

- Capsaicin is safe at recommended levels for most animal species, including poultry, cattle, and fish.
- The additive is considered safe for consumers and the environment but poses risks to users due to its irritant properties.
- Capsaicin is effective as a flavoring additive in feed under the proposed conditions of use.

## Abstract

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of capsaicin as a sensory feed additive for all animal species (flavouring compounds). The additive is specified to have a purity of at least 98% with a ratio of (E)‐capsaicin (trans‐capsaicin) to (Z)‐capsaicin (cis‐capsaicin) of ≥ 6:1. The FEEDAP Panel concludes that the additive capsaicin is safe at the recommended maximum use level proposed by the applicant (6.5 mg/kg complete feed) for use in all poultry species, all porcine species, all bovines, ovines, caprines, cervids and camelids, all equids, leporids, salmonids and minor fin fish species, dogs, ornamental birds and ornamental fish. For cats and other species not considered above, 5.3 mg/kg complete feed is considered safe. The use of capsaicin as a feed additive is considered safe for consumers and the environment. Capsaicin is a skin and respiratory irritant and is assumed to be an eye irritant. It is not a dermal sensitiser. Any exposure of users is considered a risk. The Panel concluded that the additive has the potential to be efficacious as a flavouring additive in feed for all animal species under the proposed conditions of use.

## Linked entities

- **Chemicals:** capsaicin (PubChem CID 1548943)

## Full-text entities

- **Chemicals:** (Z)-capsaicin (MESH:C117479), (E)-capsaicin (-), Capsaicin (MESH:D002211)
- **Species:** Bos taurus (bovine, species) [taxon 9913], Salmonidae (salmonids, family) [taxon 8015], Felis catus (cat, species) [taxon 9685], Canis lupus familiaris (dog, subspecies) [taxon 9615]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11983781/full.md

## References

23 references — full list in the complete paper: https://tomesphere.com/paper/PMC11983781/full.md

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Source: https://tomesphere.com/paper/PMC11983781