# Roles and regulation of δ-catenin in tumorigenesis and neuronal diseases

## TL;DR

This paper reviews the role of δ-catenin in neurological diseases and cancer, highlighting its potential as a diagnostic and therapeutic biomarker.

## Contribution

The paper provides a comprehensive review of CTNND2's signaling functions and its relevance to neuro-related diseases and cancers.

## Key findings

- CTNND2 is linked to neurological disorders like autism and Alzheimer's.
- δ-catenin is involved in cancer progression and could serve as a biomarker.
- The paper identifies gaps in current research on CTNND2 signaling.

## Abstract

CTNND2 gene is located on the short arm of human chromosome 5 and encodes δ-catenin protein, which interacts with different proteins and plays different cell functions. Studies have demonstrated that δ-catenin plays an important role in regulating synaptic maturation and neuronal integrity. The CTNND2 gene is closely associated with a variety of neurological diseases, including Cri-du-Chat syndrome, Autism spectrum disorders, Alzheimer’s disease, and Epilepsy. Furthermore, an increasing number of studies have demonstrated that CTNND2 is involved in various cancers and may serve as a novel biomarker for the diagnosis and treatment for these diseases. In this review, we will focus on the signaling regulatory functions of CTNND2 and its encoded protein δ-catenin in neuro-related diseases and cancers, and discuss the limitations of previous investigative studies and the challenges of the future researches on CTNND2 and δ-catenin signaling.