# Heterogeneous transfer learning model for improving the classification performance of fNIRS signals in motor imagery among cross-subject stroke patients

**Authors:** Jin Feng, YunDe Li, ZiJun Huang, Yehang Chen, SenLiang Lu, RongLiang Hu, QingHui Hu, YuYao Chen, XiMiao Wang, Yong Fan, Jing He

PMC · DOI: 10.3389/fnhum.2025.1555690 · Frontiers in Human Neuroscience · 2025-03-27

## TL;DR

This paper introduces a new transfer learning model that improves the classification of brain signals in stroke patients using fNIRS data, even with limited training samples.

## Contribution

The novel CHTLM model uses EEG data from healthy individuals to enhance cross-subject fNIRS classification in stroke patients.

## Key findings

- CHTLM achieved 83.1% accuracy pre-rehabilitation and 91.3% post-rehabilitation in classifying MI-fNIRS signals.
- The model outperformed five baselines by 8.6–15.7% in accuracy, demonstrating robust cross-subject generalization.
- CHTLM's performance suggests potential for monitoring stroke recovery progress using brain-computer interfaces.

## Abstract

Motor imagery functional near-infrared spectroscopy (MI-fNIRS) offers precise monitoring of neural activity in stroke rehabilitation, yet accurate cross-subject classification remains challenging due to limited training samples and significant inter-subject variability. This study proposes a Cross-Subject Heterogeneous Transfer Learning Model (CHTLM) to enhance the generalization of MI-fNIRS signal classification in stroke patients.

CHTLM leverages labeled electroencephalogram (EEG) data from healthy individuals as the source domain. An adaptive feature matching network aligns task-relevant feature maps and convolutional layers between source (EEG) and target (fNIRS) domains. Multi-scale fNIRS features are extracted, and a sparse Bayesian extreme learning machine classifies the fused deep learning features.

Experiments utilized two MI-fNIRS datasets from eight stroke patients pre- and post-rehabilitation. CHTLM achieved average accuracies of 0.831 (pre-rehabilitation) and 0.913 (post-rehabilitation), with mean AUCs of 0.887 and 0.930, respectively. Compared to five baselines, CHTLM improved accuracy by 8.6–10.5% pre-rehabilitation and 11.3–15.7% post-rehabilitation.

The model demonstrates robust cross-subject generalization by transferring task-specific knowledge from heterogeneous EEG data while addressing domain discrepancies. Its performance gains post-rehabilitation suggest clinical potential for monitoring recovery progress. CHTLM advances MI-fNIRS-based brain-computer interfaces in stroke rehabilitation by mitigating data scarcity and variability challenges.

## Linked entities

- **Diseases:** stroke (MONDO:0005098)

## Full-text entities

- **Diseases:** stroke (MESH:D020521)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

29 references — full list in the complete paper: https://tomesphere.com/paper/PMC11983500/full.md

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Source: https://tomesphere.com/paper/PMC11983500