# RETRACTION: Protective Effects of Fruit Extract of Rosa canina and Quercetin on Human Umbilical Vein Endothelial Cell Injury Induced by Hydrogen Peroxide

PMC · DOI: 10.1002/fsn3.70126 · Food Science & Nutrition · 2025-04-09

## TL;DR

A study on the protective effects of Rosa canina fruit extract and quercetin on human vein cells was retracted due to inconsistencies in data and statistical issues.

## Contribution

The paper was retracted for flawed data and statistical analysis, highlighting the importance of rigorous scientific validation.

## Key findings

- Western blot bands in Figure 4 were inconsistent with quantification graphs.
- Use of ANOVA on n=3 biological replicates was statistically inappropriate.
- Authors' provided data and explanations were insufficient to address the issues.

## Abstract

RETRACTION: F. Forouzanfar, Z. Tabatabaei, S. A. Emami, Z. Ayati and Z. Tayarani‐Najaran, “Protective Effects of Fruit Extract of 
Rosa canina
 and Quercetin on Human Umbilical Vein Endothelial Cell Injury Induced by Hydrogen Peroxide,” Food Science & Nutrition 11, no. 12 (2023): 7618–7625, https://doi.org/10.1002/fsn3.3681.

The above article, published online on 28 September 2023 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief, Y. Martin Lo; and Wiley Periodicals LLC. The retraction has been agreed upon as some of the western blot bands shown in Figure 4 are inconsistent with the corresponding quantification graphs. Furthermore, the use of the ANOVA parametric test on n = 3 biological replicates is inappropriate, leading to unreliable statistical analysis. The authors provided an explanation and some raw data, but this was deemed insufficient to resolve the flaws in the published manuscript. The editors consider the results in this article unreliable. The authors disagree with the retraction.

## Linked entities

- **Chemicals:** Hydrogen Peroxide (PubChem CID 784), Quercetin (PubChem CID 5280343)
- **Species:** Rosa canina (taxon 74635), Homo sapiens (taxon 9606)

## Full-text entities

- **Chemicals:** Rosa canina (-), Hydrogen Peroxide (MESH:D006861), Quercetin (MESH:D011794)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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Source: https://tomesphere.com/paper/PMC11982178