# Autoimmune Hypophysitis: A Cause of Central Diabetes Insipidus

**Authors:** Debashis Priyadarshan Sahoo, Bikash R Rout, Gwenette War

PMC · DOI: 10.7759/cureus.80369 · Cureus · 2025-03-10

## TL;DR

This case report explores how autoimmune hypophysitis can cause central diabetes insipidus, highlighting the challenges in diagnosis and treatment.

## Contribution

The paper presents a rare case linking autoimmune hypophysitis to central diabetes insipidus.

## Key findings

- Autoimmune hypophysitis can lead to central diabetes insipidus due to ADH deficiency.
- Diagnosis and management of this condition pose significant clinical challenges.
- Considering autoimmune hypophysitis in the differential diagnosis of DI is crucial for effective treatment.

## Abstract

Diabetes insipidus (DI) is a rare disorder characterized by polyuria and polydipsia due to a deficiency of antidiuretic hormone (ADH) or insensitivity to ADH. This case report presents a rare cause of DI secondary to autoimmune hypophysitis, emphasizing the diagnostic and management challenges associated with the condition. The discussion highlights pathophysiology, clinical presentation, diagnostic approaches, and therapeutic strategies. The importance of considering autoimmune hypophysitis in the differential diagnosis of central DI is underscored, along with long-term implications of the disease.

## Linked entities

- **Diseases:** diabetes insipidus (MONDO:0004782), autoimmune hypophysitis (MONDO:0019835)

## Full-text entities

- **Diseases:** polyuria (MESH:D011141), ADH (MESH:D007177), Autoimmune Hypophysitis (MESH:D000069281), DI (MESH:D003919), Central Diabetes Insipidus (MESH:D020790), polydipsia (MESH:D059606)

## Full text

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## References

9 references — full list in the complete paper: https://tomesphere.com/paper/PMC11981962/full.md

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Source: https://tomesphere.com/paper/PMC11981962