# Biological functionality of non-functional protein kinases **Authors:** Matthieu H A J Joosten PMC · DOI: 10.1093/jxb/eraf059 · Journal of Experimental Botany · 2025-04-09 ## TL;DR This paper explores how certain non-functional protein kinases in plants still play a role in immune responses, specifically in Arabidopsis thaliana. ## Contribution It reveals that inactive subgroup VIII receptor-like cytoplasmic kinases regulate the oxidative burst triggered by immune signals. ## Key findings - Catalytically inactive subgroup VIII kinases are essential for immune-triggered oxidative burst in Arabidopsis. - These non-functional kinases regulate immune signaling pathways despite lacking catalytic activity. - The study identifies a novel regulatory mechanism in plant immunity involving inactive protein kinases. ## Abstract This article comments on: Gonçalves Dias M, Dharmasena T, Gonzalez-Ferrer C, Maika JE, Miguel VN, Dou R, Rodriguez Gallo MC, Bredow M, Siegel KR, Uhrig RG, Simon R, Monaghan J. 2025. Catalytically inactive subgroup VIII receptor-like cytoplasmic kinases regulate the immune-triggered oxidative burst in Arabidopsis thaliana. Journal of Experimental Botany 76, 1553–1568. https://doi.org/10.1093/jxb/erae486 ## Linked entities - **Species:** Arabidopsis thaliana (taxon 3702) ## Full-text entities - **Genes:** AT3G28450 (Leucine-rich repeat protein kinase family protein) [NCBI Gene 822474] {aka BAK1-interacting receptor-like kinase 2, BIR2}, CPK28 (calcium-dependent protein kinase 28) [NCBI Gene 836753] {aka K2A18.29, K2A18_29, calcium-dependent protein kinase 28}, AT4G20565 (receptor-like kinase) [NCBI Gene 28720154], RBOHD (respiratory burst oxidase homologue D) [NCBI Gene 834842] {aka ATRBOHD, MCA23.25, MCA23_25, RESPIRATORY BURST OXIDASE, respiratory burst oxidase homologue D}, RLK (receptor lectin kinase) [NCBI Gene 818348] {aka F13M22.21, F13M22_21, L-type lectin receptor kinase IV.1, LecRK-IV.1, receptor lectin kinase}, PUB26 (plant U-box 26) [NCBI Gene 841401] {aka F14J22.1, F14J22_1, plant U-box 26}, BIK1 (botrytis-induced kinase1) [NCBI Gene 818549] {aka F12L6.32, F12L6_32, botrytis-induced kinase1}, BAK1 (BRI1-associated receptor kinase) [NCBI Gene 829480] {aka ATBAK1, ATSERK3, BRI1-associated receptor kinase, ELG, ELONGATED, F17M5.190}, EFR (EF-TU receptor) [NCBI Gene 832170] {aka EF-TU receptor, F7C8.70, F7C8_70}, PUB25 (plant U-box 25) [NCBI Gene 821472] {aka plant U-box 25} - **Chemicals:** ROS (MESH:D017382), phosphate (MESH:D010710), DFG (-), calcium (MESH:D002118) - **Species:** Escherichia coli (E. coli, species) [taxon 562], Solanum lycopersicum (tomato, species) [taxon 4081], Enterobacteria phage ST (no rank) [taxon 12354], Arabidopsis thaliana (mouse-ear cress, species) [taxon 3702] ## Full text _Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC11981891/full.md ## Figures 1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11981891/full.md ## References 15 references — full list in the complete paper: https://tomesphere.com/paper/PMC11981891/full.md --- Source: https://tomesphere.com/paper/PMC11981891