# Successful Use of Calcium Chloride in Acute Calcium Channel Blocker Overdose With Shock: A Case Report

## TL;DR

A 60-year-old woman with severe amlodipine overdose showed rapid improvement after calcium chloride treatment when standard therapies failed.

## Contribution

Demonstrates calcium chloride's effectiveness in severe CCB overdose cases unresponsive to conventional treatments.

## Key findings

- Calcium chloride led to rapid hemodynamic improvement in a patient with CCB overdose.
- Standard treatments like calcium gluconate and catecholamines were ineffective in this case.
- The case suggests calcium chloride could be a first-line antidote for severe CCB overdose.

## Abstract

Calcium channel blockers (CCBs) are widely used to treat hypertension and tachyarrhythmias. However, an overdose can lead to severe toxicity, resulting in bradycardia, hypotension, and shock. Standard treatments, including calcium gluconate and catecholamines, may be ineffective in severe cases. This study reports a 60-year-old female with hypotensive shock following an intentional overdose of amlodipine. Despite the initial treatment with calcium gluconate, glucagon, and catecholamines, hemodynamic instability persisted. However, the intravenous administration of calcium chloride resulted in rapid hemodynamic improvement, allowing eventual recovery. This case highlights the potential of calcium chloride as a first-line antidote for severe CCBs overdose refractory to conventional treatments.