# Editorial: State‐of‐the‐art hypothesis-driven systems pharmacology and artificial intelligence approaches to decipher disease complexity

**Authors:** Cristina Correia, Choong-Yong Ung, Hu Li, James C. Costello

PMC · DOI: 10.3389/fphar.2025.1593164 · 2025-03-26

## Full-text entities

- **Genes:** PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) [NCBI Gene 5291] {aka P110BETA, PI3K, PI3KBETA, PIK3C1}, RB1 (RB transcriptional corepressor 1) [NCBI Gene 5925] {aka OSRC, PPP1R130, RB, p105-Rb, p110-RB1, pRb}, TP53 (tumor protein p53) [NCBI Gene 7157] {aka BCC7, BMFS5, LFS1, P53, TRP53}, STAT6 (signal transducer and activator of transcription 6) [NCBI Gene 6778] {aka D12S1644, HIES6, IL-4-STAT, STAT6B, STAT6C}, NKX3-1 (NK3 homeobox 1) [NCBI Gene 4824] {aka BAPX2, NKX3, NKX3.1, NKX3A}
- **Diseases:** aggressiveness (MESH:D010554), lupus (MESH:D008180), gastric cancer (MESH:D013274), prostate cancer (MESH:D011471), lung cancer (MESH:D008175), cancer (MESH:D009369), hypertension (MESH:D006973), colorectal cancer (MESH:D015179), Glomerular fibrosis (MESH:D005355), kidney damage (MESH:D007674), DKD (MESH:D003928), HL (MESH:C538324), diabetes (MESH:D003920)
- **Chemicals:** blood glucose (MESH:D001786), JQ1 (-), aminoguanidine (MESH:C004479), AGE (MESH:D017127), glucose (MESH:D005947)
- **Species:** Homo sapiens (human, species) [taxon 9606]
- **Cell lines:** COLO320DM — Homo sapiens (Human), Colon adenocarcinoma, Cancer cell line (CVCL_0219), NCI-H716 — Homo sapiens (Human), Cecum adenocarcinoma, Cancer cell line (CVCL_1581), SNU16 — Homo sapiens (Human), Gastric adenocarcinoma, Cancer cell line (CVCL_0076), NCI-H2170 — Homo sapiens (Human), Lung squamous cell carcinoma, Cancer cell line (CVCL_1535)

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Source: https://tomesphere.com/paper/PMC11979609