# Severe SARS‐CoV‐2 infection in diabetes was rescued in mice supplemented with metformin and/or αKG, and patients taking metformin, via HIF1α‐IFN axis

**Authors:** Garima Joshi, Garima Verma, Simrandeep Kaur, Ellango Ramasamy, Navya Chauhan, Savita Singh, Pradipta Jana, Zaigham Abbas Rizvi, Pallavi Kshetrapal, Shinjini Bhatnagar, Anil Kumar Pandey, Amit Awasthi, Bhabatosh Das, Prasenjit Guchhait

PMC · DOI: 10.1002/ctm2.70275 · 2025-04-08

## Full-text entities

- **Genes:** HIF1A (hypoxia inducible factor 1 subunit alpha) [NCBI Gene 3091] {aka HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1}, IFNA1 (interferon alpha 1) [NCBI Gene 3439] {aka IFL, IFN, IFN-ALPHA, IFN-alphaD, IFNA13, IFNA@}
- **Diseases:** diabetes (MESH:D003920), SARS-CoV-2 infection (MESH:D000086382)
- **Chemicals:** metformin (MESH:D008687), alphaKG (-)
- **Species:** Homo sapiens (human, species) [taxon 9606], Mus musculus (house mouse, species) [taxon 10090]

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11978732/full.md

---
Source: https://tomesphere.com/paper/PMC11978732