# Editorial: SOCS: regulation of the immune system at a whole new level

**Authors:** Sandra E. Nicholson, Chulbul M. Ahmed, Karen Doggett, Daniela Marasco, Howard M. Johnson

PMC · DOI: 10.3389/fimmu.2025.1588549 · 2025-03-26

## Full-text entities

- **Genes:** Cd274 (CD274 antigen) [NCBI Gene 60533] {aka A530045L16Rik, B7h1, Pdcd1l1, Pdcd1lg1, Pdl1}, Sh2 (sperm hammerhead 2) [NCBI Gene 100125854], Foxp3 (forkhead box P3) [NCBI Gene 20371] {aka JM2, scurfin, sf}, Cd4 (CD4 antigen) [NCBI Gene 12504] {aka L3T4, Ly-4}, Ctla4 (cytotoxic T-lymphocyte-associated protein 4) [NCBI Gene 12477] {aka Cd152, Ctla-4, Ly-56}, Pdcd1 (programmed cell death 1) [NCBI Gene 18566] {aka Ly101, PD-1, Pdc1}, Cish (cytokine inducible SH2-containing protein) [NCBI Gene 12700] {aka CIS-1, CIS1, Cis, F17, F23, SOCS}, Socs2 (suppressor of cytokine signaling 2) [NCBI Gene 216233] {aka 8030460M17, CIS2, Cish2, D130043N08Rik, JAB, SOCS-2}, Il15 (interleukin 15) [NCBI Gene 16168] {aka IL-15}, Jak2 (Janus kinase 2) [NCBI Gene 16452] {aka Fd17}, Ifng (interferon gamma) [NCBI Gene 15978] {aka IFN-g, If2f, Ifg}, Il6st (interleukin 6 signal transducer) [NCBI Gene 16195] {aka 5133400A03Rik, CD130, D13Ertd699e, gp130}, Socs1 (suppressor of cytokine signaling 1) [NCBI Gene 12703] {aka Cish1, Cish7, JAB, SOCS-1, SSI-1}, Socs3 (suppressor of cytokine signaling 3) [NCBI Gene 12702] {aka Cis3, Cish3, EF-10, Ef10, SSI-3, Ssi3}, Csf2 (colony stimulating factor 2 (granulocyte-macrophage)) [NCBI Gene 12981] {aka CSF, Csfgm, GMCSF, Gm-CSf, MGI-IGM}
- **Diseases:** SLE (MESH:D008180), gastrointestinal cancer (MESH:D005770), viral (MESH:D014777), diabetic retinopathy (MESH:D003930), psoriasis (MESH:D011565), type 2 diabetes (MESH:D003924), rheumatoid arthritis (MESH:D001172), macular degeneration (MESH:D008268), inflammatory (MESH:D007249), uveitis (MESH:D014605), autoimmune and inflammatory diseases (MESH:D001327), glaucoma (MESH:D005901), cancer (MESH:D009369), DM (MESH:D009223), acute myeloid leukemia (MESH:D015470), infection (MESH:D007239), infectious diseases (MESH:D003141), allergy (MESH:D004342), KD (MESH:D009080)
- **Species:** Mus musculus (house mouse, species) [taxon 10090]

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Source: https://tomesphere.com/paper/PMC11978658