A Thrombocytopenic Thrombotic Purpura in a Patient With a Metastatic HER2+ Breast Cancer: Description of a Case Report

TL;DR

This case report describes a rare condition called paraneoplastic thrombotic thrombocytopenic purpura in a patient with advanced breast cancer.

Contribution

The novelty lies in highlighting the rare association between metastatic HER2+ breast cancer and paraneoplastic TTP, emphasizing diagnostic and management challenges.

Findings

The patient had metastatic HER2+ breast cancer and developed paraneoplastic TTP.

Diagnosis and management of this rare condition are complex and challenging.

This case underscores the importance of considering rare immune-related complications in cancer patients.

Abstract

Paraneoplastic (p) TTP is a rare syndrome characterized by an immune‐induced, generalized microangiopathy associated with solid or hematological tumors. This case, reporting a patient with a metastatic HER2+ breast cancer and a pTTP, highlights the rarity of this entity, its difficult and challenging diagnosis, and the complexity of its management.

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