# Cutaneous Adverse Events Following COVID-19 Vaccination in Japan: A Questionnaire Survey

## TL;DR

This study surveyed dermatologists in Japan to identify skin-related adverse events following COVID-19 vaccination.

## Contribution

The study provides a detailed nationwide survey of cutaneous adverse events in Japan after vaccination.

## Key findings

- Urticaria was the most common adverse event reported (74.2%).
- The mean latency from vaccination to onset was 13.1 days.
- Erythema multiforme and alopecia were frequently observed in detailed surveys.

## Abstract

We conducted a nationwide survey in Japan to clarify the clinical spectrum of these events. An initial questionnaire was sent to 126 dermatology facilities, and responses were obtained from 66 (52.4%). Among these responding facilities, the most commonly identified cutaneous adverse events after COVID-19 vaccination were urticaria (49 (74.2%)), delayed local reactions (37 (56.1%)), erythema multiforme (31 (47.0%)), and alopecia (30 (45.5%)). In the detailed survey, the primary adverse events were EM (19 (20.9%)), bullous pemphigoid (7 (7.7%)), and alopecia (6 (6.6%)). The mean latency from vaccination to onset was 13.1 days, and the mean duration of symptoms was 74.2 days. Although this study cannot establish a direct causal relationship between vaccination and adverse events, it highlights the need for dermatologists to recognize potential cutaneous reactions and provide appropriate care.